| Services |
|
|
|
|
 |
|
| News |
|
|
|
|
|
|
|
|
|
| Channels |
| Home & Family |
|
|
|
|
|
|
|
| Leisure |
|
|
|
|
| Technology |
|
|
|
|
|
| Business |
|
|
|
|
| Science |
|
|
|
|
|
|
|
|
|
|
Site Search  |
|
|
|
|
| Free email |
|
|
|
|
 |
Simple sea sponge helps scientists understand tissue rejection |
| TheallIneed.com/NC&T/MBL |
The red beard sponge (Microciona prolifera) has a cell-to-cell recognition system that, on a basic level, is similar to that of humans but much simpler. It's also a good organism for laboratory research, since its cells and cell adhesion molecules can be isolated with simple, fast, and non-disruptive methods and studied, and because its fingerlike structures make grafting experiments relatively straightforward.
In experiments carried out on these sponges this summer, Dr. Fernāndez-Busquets and his colleagues are studying the cells and molecules believed to be involved in the process of tissue rejection. By grafting together pieces of different individual sponges that will reject each othera process that approximates what sometimes happens in human transplantsthe scientists have observed that cells known as gray cells migrate to and amass at the graft site, a clear suggestion that they are involved in non-self tissue recognition and rejection. Researchers believe that gray cells may be a primitive form of our immune system's human killer cells.
 | | The red beard sponge (Photo: MBL) |
Fernāndez-Busquets has also been researching the role of the molecule called aggregation factor proteoglycan, which he has recently identified as another potential player in sponge tissue rejection reactions, and which is very easy to study in sponges. The human version of this molecule, which is different from the sponge version but similar in structure, is also believed to have important functions in cell-to-cell interactions, but is hard to study.
The ultimate goal of this research is to provide insights into the machinery behind human tissue rejection and immune responses in hopes of someday being able to control these processes and save lives.
|
| About the Author |
Š2005 All rights reserved
|
 Click here to see related videos
|
|
| Quotes | If I work incessantly to the last, nature owes me another form of existence when the present one collapses. -- Goethe, 1829
If a few idiots want to risk their necks flying across the country thats fine, but nothing will ever replace trains.
|
| Writers | | If you are a writer and want to see your article published at Theallineed.com, just click here to submit. |
|
Economic integration can spur development in Western Asia