| Services |
|
|
|
|
 |
|
| News |
|
|
|
|
|
|
|
|
|
| Channels |
| Home & Family |
|
|
|
|
|
|
|
| Leisure |
|
|
|
|
| Technology |
|
|
|
|
|
| Business |
|
|
|
|
| Science |
|
|
|
|
|
|
|
|
|
|
Site Search  |
|
|
|
|
| Free email |
|
|
|
|
 |
Neurotransmitter associated with pleasure pathways in the brain |
| TheallIneed.com/NC&T/UPSM |
Previous studies have linked orexin activity to sleep and arousal (wakefulness), as well as feeding and appetite. Anatomical studies have shown that orexin neurons extend into the brain regions associated with reward pathways, including the ventral tagmental area and nucleus accumbens. Communication between the lateral hypothalamus and these brain regions suggests that orexin neurons may have a role in motivation and reward-seeking behavior. In order to examine the relationship between orexin and reward seeking, Glenda Harris, PhD, working with Gary Aston-Jones, PhD, in the Department of Psychiatry at Penn, examined orexin function in rats using a behavioral test aimed at mimicking food- and drug-reward seeking and drug relapse. This research appeared online in Nature on August 14.
"The lateral hypothalamus has been tied to reward and pleasure for decades, but the specific circuits and chemicals involved have been elusive," says Aston-Jones. "This is the first indication that the neuropeptide orexin is a critical element in reward-seeking and drug addiction. These results provide a novel and specific target for developing new approaches to treat addiction, obesity, and other disorders associated with dysfunctional reward processing."
Harris and Aston-Jones found a strong association between the activation of orexin neurons in the lateral hypothalamus and reward seeking of morphine, cocaine, and food. Using Fos, a chemical marker of neuronal stimulation, the researchers found that the highest levels of activity in the orexin neurons appeared in rats demonstrating the greatest level of reward seeking.
The researchers demonstrated the connection between orexins and the reward pathway in three ways. First, the activation of orexin neurons is related to preferences by the rats for cues associated with drug and food rewards. Second, chemical activation of orexin neurons reinstated an extinguished drug-seeking behavior in rats. And finally, direct injection of orexin reinstated drug-seeking behavior. In addition, when the researchers administered a specific orexin antagonist, the initial learning of a drug preference and the reinstatement of extinguished drug-seeking behavior were blocked.
Because of the relationship between orexin activation and reinstatement of reward-seeking behavior, these findings may have implications for understanding drug-taking relapse in humans. An animal's reward seeking can be extinguished over time by repeatedly exposing the animal to the environment possessing drug-related cues without the previous drug rewards. After extinguishing reward seeking, presenting a stimulus that was previously associated with the drug will lead animals to quickly resume reward seeking, similar to what happens when humans have a drug relapse. Using rPP, a neuropeptide that activates orexin neurons in the lateral hypothalamus, the researchers were able to reinstate drug seeking in the rats formerly possessing extinguished drug-seeking behavior.
"These findings indicate a new set of neurons and associated neuronal receptors that are critical in consummatory reward processing," says Aston-Jones. "This provides a new target for developing drugs to treat disorders of reward processing such as drug and alcohol addiction, smoking, and obesity."
|
| About the Author |
©2005 All rights reserved
|
|
|
| Quotes | I will not expose the ignorance of the faculty. - Bart Simpson.
I want an Internet. Can I have one of those? -- Spice Girl Mel B.,aka Scary Spice, pointing to a monitor during an AOL press conference
I want to get a tatoo of myself on my entire body, only 2 taller. -- Steven Wright
I think you should defend to the death their right to march, and then go down and meet them with baseball bats.-Woody Allen, on the KKK
|
| Writers | | If you are a writer and want to see your article published at Theallineed.com, just click here to submit. |
|
Top UN officials call for release of Daw Aung San Suu Kyi
Motivational techniques you can learn starting today