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(NC&T/BU) The work could lead to treatments for memory-related disorders, as well as for the confusion and disorientation that plague elderly individuals who have trouble distinguishing between separate but similar places and experiences.
Forming memories of places and contexts in which episodes occur engages a part of the brain called the hippocampus. The laboratory of Nobel Laureate, Susumu Tonegawa, Picower Professor of Biology and Neuroscience at MIT, has been exploring how each of the three hippocampal subregions-the dentate gyrus, CA1 and CA3-contribute uniquely to different aspects of learning and memory. In the current study, co-authors Matthew Jones, Research Councils UK (RCUK) Academic Fellow in the Department of Physiology at the University of Bristol and Dr Thomas McHugh, a Picower Institute research scientist, have revealed that the learning in the dentate gyrus is crucial in rapidly recognizing and amplifying the small differences that make each place unique.
Dr Jones, commenting on the paper, said: "We constantly make split-second decisions about how best to behave at a given place and time. To achieve this, our nervous system must employ highly efficient ways of rapidly recognising and learning important changes in our environment.
"This paper demonstrates that a particular protein signalling molecule (the NMDA receptor) in a particular network of brain neurons (the dentate granule cells of the hippocampus) is essential for these rapid discrimination processes, hopefully paving the way for therapies targeting learning and behavioural disorders."
Professor Tonegawa, a frequent world traveler, describing his own occasional experience of finding the airport in a new city uncannily familiar, added: "This occurs because of the similarity of the modules-gates, chairs, ticket counters-that define the context of an airport. It is only by seeking out unique cues that the specific airport can be identified."
 | | Dentate gyrus pattern. (Photo: Matt Jones) |
Researchers believe that a set of neurons called 'place cells' fire to provide a sort of blueprint for any new space we encounter. The next time we see the space, those same neurons fire. Thus we know when we've been somewhere before and don't have to relearn our way around familiar turf. But similar spaces may activate overlapping neuronal blueprints, leaving room for confusion if the neurons are not fine-tuned.
In this study, the researchers used a line of genetically altered mice to pinpoint how the dentate gyrus contributes to the kind of pattern separation involved in identifying new and old spaces. Whilst the mice behaved normally in most situations, they became confused when required to discriminate between different spaces. This may model the difficulties in forming distinct memories for similar but distinct places and experiences that afflicts some elderly individuals.
In addition to Dr Matthew Jones, Professor Susumu Tonegawa and Dr Thomas McHugh, authors include Matthew Wilson, Picower Scholar and Professor; and colleagues from the University of California at Los Angeles and Beth Israel Deaconess Medical Center in Boston.
This work was supported by the National Institute for Mental Health and the National Institutes of Health.
How to make your home heating and cooling system cost effective? By: Ophelia Smith
Did your heating bill again knock your socks off? Why not mine? I have a 2100 plus square foot house but my heating system costs only $200 per month. As compared to me, your bill may be even more than $500. Why is there such a big difference? Let's know the basics to minimize this intolerable difference.
When it comes to my house, its visage is southern and obtains a good heat in winter seasons which turns into shade in summer. Most importantly, it is earth sheltered and on ground floor it is heated by propane heater. Additionally I have a wood stove for wintry days and even it is used for cooking whenever power is off. Higher altitude of mountainous location gives my home an appreciable air conditioning for free.
Now let's look on possible problems in your house. First of all your house may be in city where it gets little sun heat. Even though your house might be new and expensive but still I think insulation may be poor. Additionally you may have conventional gas heating and electric cooling system, both of which are expensive. In this way your house is sucking some extra money from your pocket. Obviously most of the houses in US are power controlled. So what you should do to save money? Here are three valuable strategies to do it efficiently.
1. Make sure to use less gas and power in extra efficient systems like air conditioners, hot water heaters and thermostats.
2. Insulation makes a big difference. You should try to increase insulation in structures which are not properly insulated. Cover all cabinets and shelves in the wall with doors. Also build a porch to shade the windows which will serve to save your home from hot sun. Investment in new sheet rock and insulation is required only once but your bill will come every month. Surely these are old ideas but we need to bring these ideas back to save some useful money.
3. While building your house you should ensure good science. Many builders avoid learning and doing something new so they use conventional ideas which are surely sucking our resources. Also poor quality systems are embedded in these extra large and too fragile houses. For this you need to learn all the basics so you become able to ask your builder for a higher quality.
Always remember houses built on small footprints have proved more energy efficient. Experiences have proved that smaller houses are cheaper to have proper heating and cooling system. Another way of proper heating and cooling is to stack the floors over each other. This way they work more efficiently and save some extra money. Similarly, earth sheltering is another useful approach. By this approach the under ground temperature remains 55 degree and it requires only a small amount of heating and dehumidifying. However some of these structures my not need any cooling or heating but still best thing about them is storm and fire resistance capability. Another option can be the addition of solar collectors to your yard and house. The idea of fireplace can be excellent in cold climates to have good heating environment in your house.
Does all this sounds good for you? Surely, if we go for good science rather than fashion, valuable money can be saved to invest some where else!
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| Quotes | Heres tae the fool on the hill and his pals that are down in the valley.- Wolfstone, Glass and the Can
He thought the formula for water was H-I-J-K-L-M-N-O (H-to-O).
He uses statistics as a drunken man uses lampposts — for support rather than illumination. — Andrew Lang.
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