A new method for testing allergenic substances without experimental animals
(NCYT/UG) "We have made several discoveries about the mechanism behind contact allergy, one of which is that allergenic substances react with keratin 5 and 14 in the skin. The skin cells form what are known as "blebs" when exposed to allergenic substances, and this can be used to test whether a substance is allergenic", says Sofia Andersson from the Department of Chemistry at the University of Gothenburg.
Contact allergy affects around 20% of the population in the western world. Metals such as nickel, and substances in perfume and preservatives are among the most common allergenic substances. They are often components of products that are in contact with the skin, such as jewellery, skin lotions and make up. Contact allergy cannot be cured, and an affected person must avoid the allergenic substance, in order to avoid troublesome eczema. This can be a problem if the substance is present in many different products. It is for this reason important to test cosmetic products in order to prevent the development of contact allergy.
|This is Sofia Andersson of the University of Gothenburg. (Photo: University of Gothenburg)|
"Cultured skin cells are exposed to substances for 24 hours in our test, and then photographed. The number of cells with blebs is then counted. The greater the number of blebbing cells, the more powerful is the allergenic potential of the substance. Thus, our new test has the potential to give a graded reply: it can quite simply determine whether an allergenic substance is extremely, strongly, moderately or weakly allergenic", says Sofia Andersson.
The results can then be used to determine safe concentrations of substances in products that are used in contact with the skin. Since the experiments have given very promising results, the scientists are now working together with GU Holding in developing the test and the analysis method.
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