In search of an effective method to prevent muscle wasting that comes with illness and aging, researchers have located a natural compound that is very promising.
The findings reported in Cell Metabolism (a Cell Press publication), identify a natural component of apple peels known as Ursolic Acid as a promising new nutritional therapy for the widespread and debilitating condition that affects nearly everyone at one time or another. “Muscle wasting is a frequent companion of illness and aging,” explained researchers from The University of Iowa, Iowa City. “It prolongs hospitalization, delays recoveries and in some cases prevents people going back home. It isn’t well understood and there is no medicine for it.”
The research team first looked at what happens to gene activity in muscles under conditions that promote weakening. Those studies turned up 63 genes that change in response to fasting in both people and mice and another 29 that shift their expression in the muscles of both people who are fasting and those with spinal cord injury. Comparison of those gene expression signatures to the signatures of cells treated with more than 1300 bio-active small molecules led them to ursolic acid as a compound with effects that might counteract those of atrophy.
“Ursolic Acid is an interesting natural compound,” they said. “It’s part of a normal diet as a component of apple peels. They always say that an apple a day keeps the doctor away…”
The researchers next gave Ursolic Acid to fasted laboratory subjects. Those experiments showed that ursolic acid could protect against muscle weakening as predicted. When ursolic acid was added to the food of normal subjects for a period of weeks, their muscles grew. Those effects were traced back to enhanced insulin signaling in muscle and to corrections in the gene signatures linked to atrophy.
The subjects given ursolic acid also became leaner and had lower blood levels of glucose, cholesterol and triglycerides. The findings therefore suggest that ursolic acid may be responsible for some of the overall benefits of healthy eating.
“We know if you eat a balanced diet like mom told us to eat you get this material,” the researchers explained “People who eat junk food don’t get this.”
It is not yet clear whether the findings will translate to human patients, but the goal now is to “figure out if this can help people.” If so, they don’t yet know whether Ursolic Acid at levels that might be consumed as part of a normal diet might or might not be enough.
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Apple peel is rich in flavonoids, phytochemicals and antioxidants. They are important in maintaining good health and well being. They strengthen the immune system and help the body to fight with infections. Protects From Various Cancers
To understand the advantages of apple peel for the face and skin, it’s worth understanding the nutritional value of apple peel, where apple peel could be a rich source of all sorts of vitamins, so apple peel has the potential benefits of the skin: Contains apple peel antioxidant
Apple peel helps to increase amount of brown fat in the body and lowers weight. Out body contains lot of brown fat since we are born which surrounds the main organs of the body and keeps it warm. Eliminating peel loses one third of the apple’s total fiber. It is helpful for heart diseases and diabetes.
The peel contains about 72 percent of the apple’s antioxidant vitamin E and bone-building vitamin K. The skin also holds nearly half the total iron and all of the apple’s folate. Apples produce antioxidants called flavonoids, which neutralize unstable molecules called free radicals before they damage healthy cells.
Apples are bursting with vitamins A and C, as well as important minerals such as calcium, potassium, phosphorus, folate and iron. According to Livestrong, studies have shown that much of these good-for-you nutrients are contained within the apple’s peel.
An apple with skin ON contains 50% MORE phytonutrients than a peeled one! Apple skins have exceptionally high concentrations of antioxidants. They also contain compounds (triterpenoids) with significant anti-cancer capabilities. Particularly so, when it comes to preventing liver, colon and breast cancer.
Believe it or not, apple peels can help get them clean since the acid in the apple peels can penetrate stuck on food and help it come clean easier. To use apple peels to clean your aluminum cookware, fill it with water and add apple peels. Simmer the water and apple peels for 30-45 minutes and stuck on food should come right off!
The apple peel has both soluble and insoluble fibre, but about 77 per cent of them is insoluble fibre. This fibre prevents constipation by binding with water and pushing the digestive waste through your large intestine. On the other hand, soluble fibre makes you feel full, prevents blood sugar spikes, and slows down the absorption of nutrients.
Most research focuses on apple peel and flesh. However, apple juice may have benefits for age-related mental decline. In animal studies, juice concentrate reduced harmful reactive oxygen species…
